Parkinson's disease does not begin in the brain, but in the intestines
Although the appendix is part of the gastrointestinal tract, it is often considered as a vestigular organ, which means that it does not have a vital function, and a person can live without it a healthy life. Appendix obstruction can lead to inflammation known as appendicitis, this usually requires surgical removal of the organ. Today it is known that appendix is not as useless as we thought. One of its functions is to expose leukocytes the effects of a wide range of antigens, thereby stimulating local immunity in this area. However, contrary to this information, the international group of scientists discovered that appendix can contribute to the development of Parkinson's disease. Parkinson's disease is a neurodegenerative disease that significantly affects the body's motor system. Symptoms begin slowly and gradually, sometimes with a barely noticeable tremor, and eventually develop into stiffness, problems with balance and posture, loss of automatic movements, changing the voice, and so on. Currently, scientists do not have a clear idea of what causes the disease, but they know about changes in the brain that occur during this condition. For example, certain substances in nerve cells, known as Levy Taurus, are markers of Parkinson's disease. In particular, this is the accumulation of alpha synuclein proteins. Recently, there have been a lot of talk about the hypothesis that Parkinson's disease has occurred in the intestines. Back in 1817, the English surgeon James Parksson noted that some patients suffering from the so -called “trembling paralysis” also complained about frequent constipation. In one of the six cases described by him, the treatment of gastrointestinal diseases reduced the corresponding motor problems. In this context, in a study published on October 31 in the journal Science Translational Medicine, it is reported that out of 114,4745 Swedes who did not perform appendectomy (removal of the appendix), 1608 suffered from Parkinson's disease, and out of 551003 Swedes who had adopted appendectomy, only 644 people were Parkinson's disease. This corresponds to a decrease in the likelihood of the development of the disease by 16.9%. But why? Having analyzed surgical samples, the team found that they contain an alpha synuclein protein accumulation, such as those that are found in the bodies of Levy, which most likely reach the brain where they cause the corresponding neurotoxic effect. Of course, in this field of studies there are still many studies, so the authors of publication do not yet recommend a preventive removal of appendix to people. The new international gaming club Fairspin Casino with instant payouts of almost any cryptocurrency is happy to welcome new players.